Scientific directions
Development of mathematical models and computational methods to improve the efficiency of treatment in field surgery for shrapnel injuries Group leader: Sokol Yevhen Ivanovych, Doctor of Technical Sciences, Professor. Team composition: Brief project description: The research is focused on the development of mathematical models and computational methods that optimize medical measures for shrapnel injuries in military field surgery. Using simulations and modeling algorithms, various scenarios of tissue damage, bleeding, and the body’s response to interventions are analyzed. This enables forecasting of complications, faster decision-making on-site, and adaptation of treatment protocols to the individual characteristics of the patient. Developed methods aim to improve diagnostic accuracy, surgical efficiency, and resource optimization in extreme conditions of combat injuries. Application fields: The developed mathematical models and computational methods find wide applications in the following areas: These directions contribute to improving the quality of care for injuries, reducing decision-making time, and increasing the efficiency of medical interventions under extreme conditions. Project status: The project is currently in an active stage of development and validation. Key achievements include: Future stages of the project plan to improve models based on feedback, expand computational algorithms for more accurate complication prediction, and integrate solutions into telemedicine systems for real-time support of field doctors. Contact person: Associate Professor of the Department of Applied Biomedical Engineering Kolesnik K.V.. e-mail: Kostiantyn.Kolisnyk@khpi.edu.ua Development of adaptive methods for identification and prediction of spontaneous hidden cardiopathologies Head of the group – Shchapov Pavlo Fedorovych, Doctor of Engineering Sciences, Professor. Team composition: Brief project description: Application fields: Diagnosis of cardiac activity disorders during electrocardiographic procedures and Holter monitoring of ECG. Project status: A mathematical model has been developed to identify the onset of atrial fibrillation. Using cumulative statistics methods, the possibility of short-term prediction of fibrillation has been analyzed. Publications on the topic: Matlab model of an ECG signal generator based on frequency transformation / M. A. Shyshkin [et al.] // Bulletin of the National Technical University “KhPI”. Series: New Solutions in Modern Technologies: Collection of Scientific Papers – Kharkiv: NTU “KhPI”, 2018. – № 26 (1302), Vol. 1 – Pp. 140-147. DOI:20998/2413-4295.2018.26.20 Contact person: Associate Professor of the Department of Applied Biomedical Engineering Shyshkin M.A.. e-mail: mykhailo.shyshkin@khpi.edu.ua Development of a method for determining the hydration status of patients during programmed hemodialysis. Co-organizers: NTU “KhPI” and the V.I. Shapoval Urology and Nephrology Clinical Center (Kharkiv). Brief project description (development): Creation of a mathematical description of multifactorial hydraulic processes occurring in the patient’s body during fluid removal in the programmed hemodialysis procedure. Development of a method for timely completion of the procedure upon achieving the patient’s “dry weight” state. Application field: Determining the hydration status of patients during programmed hemodialysis procedures in outpatient departments and even intensive care units. Project status: A mathematical model of fluid movement in the body during ultrafiltration has been developed and studied. A method for determining the “dry weight” of patients has been developed, which, unlike existing methods, allows continuous monitoring of ultrafiltrate volume components using bioimpedance measurement methods. This enables non-invasive, automated, and objective determination of the moment when the state of normohydration is achieved during programmed hemodialysis. A structural diagram of the device and an algorithm for the safe achievement of “dry weight” have also been developed. Implementation period: 1 year. Expected results: Creation of a prototype device for determining the “dry weight” of a patient during programmed hemodialysis. Contact person: Development of a method for obtaining additional information from bioelectrical signals. Head of the group – Shchapov Pavlo Fedorovych, Doctor of Engineering Sciences, Professor.
Team composition: Student group: Description: Utilization of intelligent information technology for processing biomedical random measurement signals (ECG, EEG, EMG) to construct metric scales of diagnosed states (quantitative state 50-100), allowing multi-alternative diagnostics at a level of 0.999. Current projects: Research on models of spectral nonstationary random biopotential signals arising in biochemical objects under the influence of regulated dynamics of factor levels. Contact person: Tomashyevskyi Roman Serhiyovych e-mail: Roman.Tomashevskyi@khpi.edu.ua Development of a new method for assessing the condition of liquid media in the body. Head of the group – Shchapov Pavlo Fedorovych, Doctor of Engineering Sciences, Professor.
Team composition: Student group: Description: Development of a biomechanical measurement device for obtaining metrological justifications of multidimensional measurement information regarding random changes induced by the mechanical impact on biopotentials, with control of spectral nonstationarity. Current projects: Development of a biomechanical measurement device and metrological support for dynamic regulation of mechanical load factors on biological samples. Contact person: Tomashyevskyi Roman Serhiyovych e-mail: Roman.Tomashevskyi@khpi.edu.ua Development of methods and devices Head of the group – Sokil Yevhen Ivanovych, Doctor of Engineering Sciences, Professor. Team composition: Student group: Description: The group focuses on the development and research of methods and devices for remote monitoring of physiological parameters of the human body. In particular, the creation of a portable telemedicine device for exchanging biomedical data via wireless communication channels. Current projects: Development of technical devices for studying the function Head of the group – Kulichenko Vyacheslav Viktorovych, Ph.D., Associate Professor. Team composition: Student group: Description: The group specializes in the design and research of technical devices for determining parameters of human external respiration function. Their work includes modeling and developing air volumetric flow sensors, improving the accuracy and sensitivity of flowmeters, as well as the design and study of spirometers. Current projects: Contact person: Tomashyevskyi Roman Serhiyovych Email: Roman.Tomashevskyi@khpi.edu.ua Determination of the state of erythrocyte plasma membranes using optical methods. Head of the group – Tomashyevskyi Roman Serhiyovych, Ph.D., Associate Professor. Team composition: Description: Determination of functional parameters of erythrocytes through mathematical processing of their holographic images followed by statistical analysis. This method enables the diagnosis of diseases at the membrane level and the selection of appropriate therapy that adheres to international WHO standards for diagnosis and treatment. Current projects: Holographic system for determining the state of erythrocyte plasma membranes. Contact person: Tomashyevskyi Roman Serhiyovych Email: Roman.Tomashevskyi@khpi.edu.ua Modeling physiological processes in the human body. Head of the group – Lapta S.S., Ph.D., Associate Professor. Team composition: Description: Development of medical devices and systems based on physiologically adequate models of physiological processes. Through modeling, the goal is to derive functional characteristics of diagnostic systems that are inaccessible for direct measurement from available integrated clinical data. Publications on the topic: Current projects: Contact person: Lapta Stanislav Serhiyovych Email: stas69@ukr.net Determination of the antioxidant activity of food products. Head of the group – Tomashyevskyi Roman Serhiyovych, Ph.D., Associate Professor. Team composition: Student group: Description: Determination of the antioxidant activity of food products using the coulometric titration method with electrogenerated bromine, along with the creation of a device employing this method. Publications on the topic: YSF 2016. Device for the Integrated Evaluation of Antioxidant Activity of Foods. Current projects: Device for integral evaluation of the antioxidant activity of food products. Contact person: Tomashyevskyi Roman Serhiyovych Email: romiocat.khpi@gmail.com Development of methods and technical devices for accurate ozone dosing during systemic ozone therapy procedures. Team composition: Description: The group focuses on analyzing the interaction processes of ozone-oxygen mixtures with liquids, including human blood. Their work involves developing methods and equipment for preparing medical substances and performing ozone therapy procedures. Additionally, they research methods and apparatuses for analyzing the effects of ozone on the human body. Current projects: Contact person: Makhonin Mykola Vitaliyovych
Kolesnik K.V., Ph.D., Associate Professor
Kulichenko V.V., Ph.D., Associate Professor
Shyshkin M. A. Comparative evaluation of ECG signal compression methods for telemedicine tasks / M. A. Shyshkin, K. V. Kolesnik // Bulletin of the National Technical University “KhPI”: Collection of Scientific Papers. Special Issue: New Solutions in Modern Technologies – Kharkiv: NTU “KhPI”. – 2014. – № 36 (1079). – Pp. 149-155.
for telemedicine.
of external respiration.