The research presents multidisciplinary scale of e-learning in the context of digital transformations, caused by the range of modern crises. A proposed innovative approach considers e-learning as an integral component of the holistic process of students’ cognitive, professional and personality self-development. Student’s synergetic interaction with e-developmental environment as innovative ecosystem involves a big variety of e-training activities based on the model of multidisciplinary project development. Ecosystem complexity determines the diversity of interaction modes. Student’s profile as agent of positive changes in the target professional field and society presents system-forming factor.